澳门赌城app下载(澳门星赌app下载) is widely used in the pharmaceutical industry for the purposes of drug discovery, API合成, 以及分析应用. It is also an excipient solvent in pharmaceutical drug delivery systems. Procipient® (Dimethyl Sulfoxide USP, Ph. 欧元.) addresses the quality and regulatory requirements, 按照FDA的要求, 对于这些特定的应用. 澳门星赌app下载 协助选择职系.
澳门赌城app下载(DMS) is primarily used in the synthesis of Active Pharmaceutical Ingredients. 以磺酸盐的形式, it acts as a reagent in the synthesis of borane reducing agents (BH3-DMS) and is also utilized in epoxidation and hydroboration-oxidation reactions.
应用程序
药物输送
Procipient®(Dimethyl Sulfoxide USP, Ph. 欧元.) is used in topical and parenteral drug delivery. Details of 澳门星赌app下载 in approved products can be located in the U.S. Food and Drug Administration-Center for Drug Evaluation and Research’s database Inactive Ingredient 搜索 for Approved Drug 产品.
局部剂量
Procipient®(Dimethyl Sulfoxide USP, Ph. 欧元.) has been recognized for many years as a topical penetration enhancer. Both human and animal health applications currently exist which use 澳门星赌app下载 in this role.
Solvent properties of 澳门星赌app下载 may be beneficial in that higher loading of the API in semisolid products can sometimes be achieved.
The low vapor pressure of 澳门星赌app下载 enables formulations to absorb without the skin-chilling effect of excipients such as alcohol.
从公式的角度来看, 澳门星赌app下载 viscosity is similar to water and 澳门星赌app下载 can serve as a way to lower formulation viscosity. The addition of traditional thickening agents (Carbopol®, Klucel®, 甲基纤维素®, Tylose®) can be a way to increase 澳门星赌app下载 viscosity allowing for optimally designed dosage forms.
注射用药物的剂量
Approved applications for this route of administration exist for Procipient® (Dimethyl Sulfoxide USP, Ph欧元) where it provides solubility to the API. 在世界范围内, many innovative applications are currently being evaluated for small volume parenteral products and vaccines.
Emerging applications include autologous cell processing and the delivery (or processing) of carbohydrates using a compendial 澳门星赌app下载 product. 澳门星赌app下载 may also act as a process aid for biopolymers used in parenteral dosage forms.
Procipient® has been used as an excipient to solubilize the drug product to be delivered as a long acting injectable and to dissolve medical polymers like EVOH, Chinese民解放军, PLGA and other biomaterials that precipitate in situ to form biodegradable implants.
作为API
Procipient® is approved throughout the world as an API (Active Pharmaceutical Ingredient) for the treatment of Interstitial Cystitis. The approved formulation is a sterile 50% aqueous 澳门星赌app下载 solution that is instilled into the bladder.
While this is the only approved indication for 澳门星赌app下载 in North America 澳门星赌app下载, it is used on other parts of the world as a topical anti-inflammatory in addition to traditional self-medication applications.
低温贮藏
澳门星赌app下载 is well known in 低温贮藏. Procipient® is an ingredient in cryo-media for the cryopreservation of cells and biological tissue for various end use applications.
澳门星赌app下载 passes through cell membranes 比甘油更容易吸收.
When combined with water, 澳门星赌app下载 exhibits unique and interesting thermodynamic properties. The eutectic mixture of the combination results in a liquid at minus 80°C 澳门星赌app下载/Water, preventing damaging the cells from ice formation and disrupting cellular structure while maintaining viability of the cells.
分析
Various instrumental methods require consistent solvents with well characterized impurity profiles.
澳门星赌app下载 can be used in analytical applications and excels due to the wide range of materials 澳门星赌app下载 will dissolve.
澳门星赌app下载可用于:
- The analysis of polymers, inorganic and organic compounds by UV and IR spectroscopy.
- As a solvent in the preparation of samples for HPLC analysis and is an ‘universal solvent’ for poorly soluble drugs.
We manufacture two grades of 澳门星赌app下载 conforming to ACS (American Chemical Society’s) Monographs.
澳门星赌app下载 ACS试剂等级 光纯度越高 澳门星赌app下载 ACS分光光度等级.
复合存储
澳门星赌app下载 exhibits outstanding solvent capability for both organic and inorganic compounds.
These characteristics make 澳门星赌app下载 a widely used solvent in compound discovery laboratories for compound library storage. 澳门星赌app下载 is also used in analytical or High Throughput Screening processes.
通常 澳门星赌app下载 ACS分光光度等级 是否被选择用于库存储.
的洁净杂质轮廓 澳门星赌app下载 ACS分光光度等级 insures the 澳门星赌app下载 will remain a consistent background that doesn’t contribute interferences.
合成
澳门星赌app下载 has been an essential part of numerous 药物合成 that are currently in various clinical trial stages or commercial phases.
唑类, Quinolone antibiotics and macrolides are some specific pharmacological drug classes which benefit from the use of 澳门星赌app下载.
As a reagent, 澳门星赌app下载 is key to a class of mild and selectivity oxidation reactions. 澳门星赌app下载 can be used to form the dimsyl ion, which is a strong base useful in alkylation, nucleophilic displacement and condensation reactions.